Genomic Characterization of Campylobacter jejuni Strain M1

Friis, C; Wassenaar, TM; Javed, MA; Snipen, Lars-Gustav; Lagesen, Karin; Hallin, PF; Newell, DG; Toszeghy, M; Ridley, A; Manning, G; Ussery, David Wayne

dc.creator	Friis, C
dc.creator	Wassenaar, TM
dc.creator	Javed, MA
dc.creator	Snipen, Lars-Gustav
dc.creator	Lagesen, Karin
dc.creator	Hallin, PF
dc.creator	Newell, DG
dc.creator	Toszeghy, M
dc.creator	Ridley, A
dc.creator	Manning, G
dc.creator	Ussery, David Wayne
dc.date	2014-01-06T10:37:21Z
dc.date	2014-01-06T10:37:21Z
dc.date	2010
dc.date	2014-01-06T10:37:21Z
dc.date.accessioned	2023-03-08T18:37:32Z
dc.date.available	2023-03-08T18:37:32Z
dc.identifier	PLoS ONE 2010, 5(8)
dc.identifier	http://hdl.handle.net/123456789/4515
dc.identifier	10.1371/journal.pone.0012253
dc.identifier	519377
dc.identifier.uri	http://hdl.handle.net/123456789/3840
dc.description	Campylobacter jejuni strain M1 (laboratory designation 99/308) is a rarely documented case of direct transmission of C. jejuni from chicken to a person, resulting in enteritis. We have sequenced the genome of C. jejuni strain M1, and compared this to 12 other C. jejuni sequenced genomes currently publicly available. Compared to these, M1 is closest to strain 81116. Based on the 13 genome sequences, we have identified the C. jejuni pan-genome, as well as the core genome, the auxiliary genes, and genes unique between strains M1 and 81116. The pan-genome contains 2,427 gene families, whilst the core genome comprised 1,295 gene families, or about two-thirds of the gene content of the average of the sequenced C. jejuni genomes. Various comparison and visualization tools were applied to the 13 C. jejuni genome sequences, including a species pan- and core genome plot, a BLAST Matrix and a BLAST Atlas. Trees based on 16S rRNA sequences and on the total gene families in each genome are presented. The findings are discussed in the background of the proven virulence potential of M1.
dc.description	Campylobacter jejuni strain M1 (laboratory designation 99/308) is a rarely documented case of direct transmission of C. jejuni from chicken to a person, resulting in enteritis. We have sequenced the genome of C. jejuni strain M1, and compared this to 12 other C. jejuni sequenced genomes currently publicly available. Compared to these, M1 is closest to strain 81116. Based on the 13 genome sequences, we have identified the C. jejuni pan-genome, as well as the core genome, the auxiliary genes, and genes unique between strains M1 and 81116. The pan-genome contains 2,427 gene families, whilst the core genome comprised 1,295 gene families, or about two-thirds of the gene content of the average of the sequenced C. jejuni genomes. Various comparison and visualization tools were applied to the 13 C. jejuni genome sequences, including a species pan- and core genome plot, a BLAST Matrix and a BLAST Atlas. Trees based on 16S rRNA sequences and on the total gene families in each genome are presented. The findings are discussed in the background of the proven virulence potential of M1.
dc.language	eng
dc.source	1932-6203
dc.title	Genomic Characterization of Campylobacter jejuni Strain M1
dc.title	Genomic Characterization of Campylobacter jejuni Strain M1
dc.type	Journal article