dc.date.accessioned |
2023-03-01T09:21:59Z |
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dc.date.available |
2023-03-01T09:21:59Z |
|
dc.date.created |
2012-03-28T16:31:02Z |
|
dc.date.issued |
2012 |
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dc.identifier.citation |
Ahlen, Maria Therese, Husebekk, Anne, Killie, Mette Kjær, Kjeldsen-Kragh, Jens, Olsson, Martin L., Skogen, Bjørn Ragnar. The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes. Clinical & Developmental Immunology 2012 |
|
dc.identifier.issn |
1740-2522 |
|
dc.identifier.uri |
http://hdl.handle.net/123456789/1894 |
|
dc.description.abstract |
Background. Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995–2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies. Design and Methods. A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, and severe thrombocytopenia in the newborn was investigated. Results. We observed that immunized women with blood group O had a lower risk of having a child with severe NAIT than women with group A; 20% with blood group O gave birth to children with severe NAIT, compared to 47% among the blood group A mothers (relative risk 0.43; 95% CI 0.25–0.75). Conclusion. The risk of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO types, and this study indicates that the observation is due to genetic properties on the maternal side. |
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dc.language |
EN |
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dc.title |
The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to Maternal ABO Genotypes |
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dc.type |
Academic article |
|
cristin.unitcode |
185,53,18,12 |
|
cristin.unitname |
Avdeling for immunologi og transfusjonsmedisin |
|
cristin.ispublished |
true |
|
cristin.qualitycode |
1 |
|
dc.creator.author |
Ahlen, Maria Therese |
|
dc.creator.author |
Husebekk, Anne |
|
dc.creator.author |
Killie, Mette Kjær |
|
dc.creator.author |
Kjeldsen-Kragh, Jens |
|
dc.creator.author |
Olsson, Martin L. |
|
dc.creator.author |
Skogen, Bjørn Ragnar |
|
dc.identifier.cristin |
918006 |
|
dc.identifier.bibliographiccitation |
info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical & Developmental Immunology&rft.volume=2012&rft.date=2012 |
|
dc.identifier.jtitle |
Clinical & Developmental Immunology |
|
dc.identifier.volume |
2012 |
|
dc.identifier.pagecount |
5 |
|
dc.identifier.doi |
http://dx.doi.org/10.1155/2012/156867 |
|
dc.type.document |
Artikkel |
|